Efficacy and Safety of Ciprofol in Laparoscopic Sleeve Gastrectomy

Summary

To evaluate the efficacy and safety of ciprofol for the induction of general anesthesia in obese patients undergoing laparoscopic sleeve gastrectomy. A randomized, parallel, propofol injection positive control study will be conducted to select obese patients who will undergo laparoscopic sleeve gastrectomy in the author's hospital. To evaluate the efficacy and safety, the main observation index, secondary observation indexes, safety evaluation indexes, and the incidence of postoperative adverse reactions will be recorded and compared between the two groups.

Timeline

Start

2023-01-01

Primary completion

2023-06-30

Completion

2024-07-30

Outcome

Met primary endpoint

paper The success rates of anesthesia induction were 100% in both groups. PMID 40705792 ↗

paper Ciprofol demonstrated non-inferiority to propofol in induction success. PMID 40705792 ↗

Publications

• Chi X, Xu Y, Li Q, Xia K, Fu Q. Efficacy and safety of ciprofol for the induction of general anesthesia in patients with obesity undergoing laparoscopic sleeve gastrectomy: A double-blind randomized, controlled study. PLoS One. 2025 Jul 24;20(7):e0329005. doi: 10.1371/journal.pone.0329005. eCollection 2025.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Cipepofol	Small molecule	0.4 mg/kg	Intravenous
Subject	Cipepofol	Small molecule	0.5 mg/kg	Intravenous
Comparator	Propofol	Small molecule	2 mg/kg	Intravenous
Comparator	Propofol	Small molecule	2.5 mg/kg	Intravenous

Indications

No indication recorded.