drugset / Trial / NCT05547750
Effect of Vitamin K2 in the Treatment of Nocturnal Leg Cramps in Older Population
Completed
200 enrolled
The Third People's Hospital of Chengdu
Affiliated Hospital of North Sichuan Medical College · collab
RandomizedParallel-groupTriple-blindTreatment
Summary
Nocturnal leg cramps (NLCs) are sudden contractions of the leg muscles, usually in the posterior calf muscles at night, affecting sleep quality. Because the precise pathophysiology of NCLs is unclear, different interventions have been proposed. There is conflicting evidence regarding the efficacy of conventional interventions in preventing cramps. Thus, the present study aims to investigate the effects of vitamin K2 for NLCs in a prospective randomized, double-blind, controlled trial.
Timeline
- Start
- 2022-10-01
- Primary completion
- 2023-12-31
- Completion
- 2023-12-31
Publications
- Tan J, Zhu R, Li Y, Wang L, Liao S, Cheng L, Mao L, Jing D. Vitamin K2 in Managing Nocturnal Leg Cramps: A Randomized Clinical Trial. JAMA Intern Med. 2024 Dec 1;184(12):1443-1447. doi: 10.1001/jamainternmed.2024.5726.
- Li Y, Zhu R, Wang L, Tan J. Effect of vitamin K2 in the treatment of nocturnal leg cramps in the older population: Study protocol of a randomized, double-blind, controlled trial. Front Nutr. 2023 Feb 23;10:1119233. doi: 10.3389/fnut.2023.1119233. eCollection 2023.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Vitamin K2 | Unknown | 180 ug | Oral |
Indications
No indication recorded.