Semaglutide Treatment, Appetite, and Eating Behavior: Long-term Effects

Summary

This study will evaluate the effect of semaglutide on eating behavior, appetite (hunger/fullness), and food liking in the long-term, as compared to placebo. All participants will receive lifestyle modification (diet and exercise) counseling, and will be prescribed the FDA-approved weight loss medication, semaglutide, or placebo (an inactive saline solution) for 72 weeks.

Timeline

Start

2022-07-26

Primary completion

2025-05-12

Completion

2025-05-12

Publications

• Tronieri JS, Allison KC, DeRouen K, Amaro A, Collins KG, Roy A, Watts S, Ananna T, Wadden TA. Short- and Long-term Effects of Semaglutide 2.4 mg on Energy Intake, Appetite, and Food Reward: A 60-week, Double-Blind Randomized Controlled Trial. Am J Clin Nutr. 2026 Jun 20:101403. doi: 10.1016/j.ajcnut.2026.101403. Online ahead of print.
• Gordon K, Matthews A, Zeller MH, Lin J. Practical guidelines for eating disorder risk mitigation in patients undergoing obesity treatment for the pediatric provider. Curr Opin Pediatr. 2024 Aug 1;36(4):367-374. doi: 10.1097/MOP.0000000000001356. Epub 2024 Apr 5.

Drugs

Indications