BURAN: Benralizumab on Airway Dynamics in Severe Eosinophilic Asthma Using Functional Respiratory Imaging

Summary

This study will assess the effects of benralizumab on airway dynamics in severe eosinophilic asthma in terms of quantitative computed tomography (CT)-derived measurements of pulmonary structure and function using the Functional Respiratory Imaging (FRI) platform.

Timeline

Start

2022-10-11

Primary completion

2024-07-19

Completion

2024-07-19

Publications

• Carstens DD, De Backer W, Rhodes K, Muchmore P, Lavon BR, Chung SYE, Fogel R, Trudo F, Panettieri R Jr. Impact of benralizumab on airway structure/function in severe eosinophilic asthma. Respir Res. 2026 Jul 15. doi: 10.1186/s12931-026-03742-y. Online ahead of print.
• Genofre E, Carstens D, DeBacker W, Muchmore P, Panettieri RA Jr, Rhodes K, Shih VH, Trudo F. The effects of benralizumab on airway geometry and dynamics in severe eosinophilic asthma: a single-arm study design exploring a functional respiratory imaging approach. Respir Res. 2023 May 3;24(1):121. doi: 10.1186/s12931-023-02415-4.

Drugs

Indications