drugset / Trial / NCT05565378

A Platform Study of Novel Immunotherapy Combinations in Participants With Previously Untreated, Advanced/Metastatic Non-Small-Cell Lung Cancer

NCT05565378

Phase 2 Active not recruiting 351 enrolled GlaxoSmithKline iTeos Therapeutics · collab
RandomizedParallel-groupOpen-labelTreatment

Summary

This study will monitor the safety of novel immunotherapy combinations in participants with Programmed death ligand-1 (PD L-1) high (Tumor cells \[TC\]/ Tumor proportion score \[TPS\] \>= 50%), previously untreated, unresectable, locally advanced or metastatic non-small cell lung cancer (NSCLC). Drug name mentioned as Belrestotug, GSK4428859A, and EOS884448 are all interchangeable for the same compound. In the rest of the document, the drug will be referred to as Belrestotug.

Timeline

Start
2022-10-14
Primary completion
2026-11-09
Completion
2027-12-06

Drugs

EvaluationDrugModalityDoseRoute
Subject Belrestotug Monoclonal antibody
Subject Dostarlimab Monoclonal antibody
Subject Nelistotug Monoclonal antibody
Comparator Pembrolizumab Monoclonal antibody