drugset / Trial / NCT05565417
Study of the Monoclonal Antibody IMT-009 in Patients With Advanced Solid Tumors or Lymphomas
Non-randomizedSequentialOpen-labelTreatment
Summary
This is a Phase 1/2a open-label, multicenter, dose escalation and dose expansion trial in which IMT-009 will be administered by the intravenous (IV) route to participants with solid tumors or lymphomas. The main goals of this study are to: * Find the recommended dose of IMT-009 that can be safely given to participants * Learn more about the side effects of IMT-009 * Learn more about pharmacokinetics of IMT-009 * Learn more about the effectiveness of IMT-009 * Learn more about different pharmacokinetic biomarkers and how they might change in the presence of IMT-009
Timeline
- Start
- 2022-11-28
- Primary completion
- 2026-01
- Completion
- 2026-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | REZORSTOBART | Monoclonal antibody | — | Intravenous |
| Background | Fruquintinib | Small molecule | — | — |
Indications
Burkitt lymphoma
Hodgkins lymphoma
colorectal cancer
diffuse large B-cell lymphoma
esophageal cancer
follicular lymphoma
head and neck squamous cell carcinoma
hormone receptor-positive breast cancer
non-small cell lung carcinoma
skin squamous cell carcinoma
small intestine cancer
triple-negative breast carcinoma