Fecal Microbial Transplantation in Critically Ill Patients With Severe Infections.

Summary

Fecal microbial transplantation is to transplant functional microbiota from the feces of healthy people into the gastrointestinal tract of patients, reconstruct new intestinal microbiota, and realize the treatment of intestinal and extra-intestinal diseases. Compared with ordinary commercial probiotics, FMT is more consistent with the composition of the intestinal microecological structure and can recover intestinal flora to the maximum extent and faster. FMT increases intestinal bacteria production function and helps to restore the systemic immune response so that sepsis pathogens are removed. The aim of this trial was to investigate the clinical effect of FMT in the treatment of patients with severe infections.

Timeline

Start

2022-09-04

Primary completion

2024-12-31

Completion

2025-12-31

Publications

• Background Haak BW, Prescott HC, Wiersinga WJ. Therapeutic Potential of the Gut Microbiota in the Prevention and Treatment of Sepsis. Front Immunol. 2018 Sep 10;9:2042. doi: 10.3389/fimmu.2018.02042. eCollection 2018.
• Chen Y, Zhao J, Zhao J, Chen Q, Dong S, Jia S, Zhao Y, Hao D, Yin Y, Lin S, Chen Y, Zhuang Y, Peng H. Effects of fecal microbiota transplantation and probiotics on the gut microbiome in antibiotic-treated septic patients: A pilot randomized controlled trial. Virulence. 2026 Dec;17(1):2668764. doi: 10.1080/21505594.2026.2668764. Epub 2026 May 22.

Drugs

Indications