drugset
drugset / Trial / NCT05578859

A Study of the Absorption, Metabolism, and Excretion of [14C]-AMG 510 Following a Single Oral Dose in Healthy Male Subjects

NCT05578859 ↗

Phase 1 Completed 8 enrolled Amgen
NaSingle-groupOpen-labelBasic science

Summary

The primary objectives of the study are: to characterize the primary route(s) of elimination of \[14C\]-AMG 510 and drug-related material, and estimate the overall recovery of radiolabeled material in healthy male participants after oral administration of \[14C\]-AMG 510, and to characterize the pharmacokinetic (PK) of total radioactivity and AMG 510 following a single oral dose of \[14C\]-AMG 510 in healthy male participants.

Timeline

Start
2020-03-11
Primary completion
2020-03-24
Completion
2020-03-24

Drugs

EvaluationDrugModalityDoseRoute
Subject Sotorasib Small molecule — Oral

Indications

No indication recorded.