Experience With Topical Acne Treatment
Summary
Acne is a chronic condition that typically requires the use of multiple medications.1 Medication adherence is especially challenging for patients with chronic diseases and often decreases over time, especially for those using topical medications.1 Nonadherence can result in multiple negative effects including treatment failure, increased healthcare costs, and decreased quality of life. Primary nonadherence refers to problems acquiring and starting treatment. Challenges to this form of nonadherence include a lack of knowledge, misunderstanding of usage, poor communication with provider, increased cost, and fear of side effects.2 Secondary nonadherence refers to when the patient does not use the medication as prescribed. Hurdles to secondary nonadherence include delayed results, increased complexity of treatment plan, adverse effects, busy lifestyle, and inconvenience.2
Timeline
- Start
- 2024-02-15
- Primary completion
- 2025-06-19
- Completion
- 2026-11
Publications
- Background Lott R, Taylor SL, O'Neill JL, Krowchuk DP, Feldman SR. Medication adherence among acne patients: a review. J Cosmet Dermatol. 2010 Jun;9(2):160-6. doi: 10.1111/j.1473-2165.2010.00490.x.
- Background Moradi Tuchayi S, Alexander TM, Nadkarni A, Feldman SR. Interventions to increase adherence to acne treatment. Patient Prefer Adherence. 2016 Oct 11;10:2091-2096. doi: 10.2147/PPA.S117437. eCollection 2016.
- Background Tan X, Al-Dabagh A, Davis SA, Lin HC, Balkrishnan R, Chang J, Feldman SR. Medication adherence, healthcare costs and utilization associated with acne drugs in Medicaid enrollees with acne vulgaris. Am J Clin Dermatol. 2013 Jun;14(3):243-51. doi: 10.1007/s40257-013-0016-x.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Adapalene | Other / unclassified | 0.1 % | Topical |
| Subject | BPO | Unknown | 2.5 % | Topical |
| Subject | Clindamycin | Unknown | 1.2 % | Topical |
| Subject | Epiduo® Forte | Unknown | 0.3 % | Topical |
| Subject | Epiduo® Forte | Unknown | 2.5 % | Topical |
| Subject | clindamycin phosphate 1.2%/adapalene 0.15%/BPO 3.1% gel | Unknown | 0.15 % | Topical |
| Subject | clindamycin phosphate 1.2%/adapalene 0.15%/BPO 3.1% gel | Unknown | 1.2 % | Topical |
| Subject | clindamycin phosphate 1.2%/adapalene 0.15%/BPO 3.1% gel | Unknown | 3.1 % | Topical |