Investigation of the Distinct Mechanisms Involved in Inflammatory Resolution Between Healthy Men and Women

Phase 0 Active not recruiting 34 enrolled Queen Mary University of London

Non-randomizedParallel-groupOpen-labelBasic science

Summary

Important differences exist between sexes in incidence, disease patterns and outcomes in coronary artery disease that is not well understood. It is likely that key differences in the underlying biological mechanism, in particular in inflammatory responses, play a part in underpinning these differences. Previous evidence demonstrates that healthy females appear to be more adept at resolving inflammation compared to healthy males. Since inflammation is thought to be a key initiating phenomenon in coronary artery disease the investigators will examine the differences in inflammatory resolution between the sexes in healthy volunteers.

Timeline

Start: 2022-12-12
Primary completion: 2027-12-12
Completion: 2027-12-12

Publications

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Cantharidin	Small molecule	0.01 ml	Topical
Subject	Cantharidin	Small molecule	0.1 %	Topical

Indications

No indication recorded.