drugset / Trial / NCT05598580
Immunomodulators on HIV-1 Reservoir
RandomizedParallel-groupOpen-labelTreatment
Summary
The goal of this clinical trial is to learn about the function of immunomodulators in reducing HIV reservoir. The main questions it aims to answer are: * Are immunomodulators able to reduce HIV reservoirs? * How do immunomodulators reduce HIV reservoirs? Participants will be randomly and equally divided into three groups, one control group and two trial groups. All three groups will continue to receive antiretroviral therapy. The two experimental groups will additionally be given different immunomodulators lenalidomide and adenosylmethionine, respectively. The effectiveness of immunomodulatory agents in reducing viral reservoirs will be explored by comparing relevant indicators in the three groups.
Timeline
- Start
- 2022-11-20
- Primary completion
- 2024-05
- Completion
- 2024-11
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Ademetionine | Unknown | 1000 mg | Oral |
| Subject | Lenalidomide | Other / unclassified | 25 mg | Oral |