drugset / Trial / NCT05598580

Immunomodulators on HIV-1 Reservoir

NCT05598580

RandomizedParallel-groupOpen-labelTreatment

Summary

The goal of this clinical trial is to learn about the function of immunomodulators in reducing HIV reservoir. The main questions it aims to answer are: * Are immunomodulators able to reduce HIV reservoirs? * How do immunomodulators reduce HIV reservoirs? Participants will be randomly and equally divided into three groups, one control group and two trial groups. All three groups will continue to receive antiretroviral therapy. The two experimental groups will additionally be given different immunomodulators lenalidomide and adenosylmethionine, respectively. The effectiveness of immunomodulatory agents in reducing viral reservoirs will be explored by comparing relevant indicators in the three groups.

Timeline

Start
2022-11-20
Primary completion
2024-05
Completion
2024-11

Drugs

EvaluationDrugModalityDoseRoute
Subject Ademetionine Unknown 1000 mg Oral
Subject Lenalidomide Other / unclassified 25 mg Oral