PET Synaptogenesis After Psilocybin In DEpression Recovery

Summary

Participants with depression will be given a single dose of psilocybin and supportive psychotherapy before, during, and after drug administration. Participants will undergo positron emission tomography (PET) imaging before and one week after psilocybin using a marker of synaptic density. This design allows us to assess the relationship between neurotrophic, and antidepressant effects produced by psilocybin.

Timeline

Start

2023-07-01

Primary completion

2025-01-01

Completion

2025-07-01

Outcome

Outcome not reported

Stopped: “Due to negative results in similar trials using 11C-UCB-J”

Drugs

Indications