Vorinostat in Combination With Chemoradiation in Locally Advanced HPV Negative HNSCC

Summary

The purpose of this study is to learn more about a drug called Vorinostat (an experimental drug) in combination with chemoradiation. The intention of this study is to learn if this drug is safe for the participants and whether this drug with chemoradiation is able to further increase the clinical efficacy of chemoradiation, which is an approved therapy. The main question it aims to answer is: How may Vorinostat interact with standard chemotherapy and radiation therapy in head and neck cancer? Participants will receive the study drug (Vorinostat) as a pre-treatment, followed by standard chemoradiation.

Timeline

Start

2025-06-01

Primary completion

2025-08-01

Completion

2026-02-01

Drugs

Indications