The Cold Fluids Study

Summary

In this single center crossover study the aim is to investigate the effect of Ringer's lactate solution at high and low temperatures on physiological response in healthy adults.18 healthy volunteers will be included. Inclusion criteria is; Age between 18-64. Exclusion criteria is; Pre-existing medical problems, Pregnancy (validated through a certified pregnancy test), Body mass index \>35 kg/m2, Medication use apart from allergy medication, contraceptives, or non-steroidal anti-inflammatory drugs. Participants will be randomized to receive 30 ml/kg of Ringer's lactate either cold (15°C, 59°F), or at body temperature (37°C, 98.6°F) during a 30-minute interval. Fluids will be administered through a peripheral vein. After a minimum "washout period" of 24 hours, subjects are switched to receive infusion at the other aforementioned temperatures. Primary outcome is * The increase in MAP at 15 minutes after infusion of the fluid bolus. Secondary outcome is * Time until return of MAP to baseline value after infusion.

Timeline

Start

2022-10-24

Primary completion

2022-12-03

Completion

2022-12-03

Publications

• Biesenbach P, Molmer MB, Svendsen EL, Teichmann D, Wuthe S, Momeni M, Kristensen MR, Laugesen LE, Berg-Beckhoff G, Bentsen LP, Bergmann ML, Brabrand M. Ringer's lactate administered at 15 degrees C leads to a greater and more prolonged increase in blood pressure compared to 37 degrees C. Sci Rep. 2024 Oct 26;14(1):25592. doi: 10.1038/s41598-024-76858-0.

Drugs

Indications

No indication recorded.