drugset / Trial / NCT05614453

Tislelizumab in Combination With Sitravatinib for Recurrent/Metastatic Cervical Cancer After Platinum-Based Chemotherapy

NCT05614453 ↗

NaSingle-groupOpen-labelTreatment

Summary

The goal of this clinical trial is to learn about the effect of the combination treatment of sitravatinib with tislelizumab in patients with Recurrent/Metastatic Cervical Cancer after Platinum-Based Chemotherapy. The main question it aims to answer is the percentage of people in the study who have a partial or complete response to the treatment. Participants will receive treatment under the care of their treating physician and will be reviewed regularly.

Timeline

Start
2023-06
Primary completion
2023-06
Completion
2023-06-28

Outcome

Outcome not reported

Stopped: “BeiGene has withdrawn their support owing to sitravatinib supply concerns. Mirati is ceasing further development of sitravatinib owing to the negative results of the SAPPHIRE trial which used sitravatinib in 2nd line met NSCLC setting.”

Drugs

EvaluationDrugModalityDoseRoute
Subject Sitravatinib Small molecule 100 mg Oral
Subject Tislelizumab Monoclonal antibody 200 mg Intravenous

Indications