Inhaled Nitric Oxide for Microvascular Dysfunction in Traumatic Brain Injury

Summary

Traumatic brain injury (TBI) causes acute deficits in cerebral perfusion which may lead to secondary injury and worse outcomes. Inhaled nitric oxide (iNO) is a vasodilator that increases cerebral blood flow and is clinically used for hypoxic respiratory failure in neonates and adults. The investigators will perform a randomized controlled trial of iNO treatment in TBI patients acutely after injury. The investigators will then assess perfusion changes with optic neuromonitoring, blood biomarkers, and 6 month clinical outcomes.

Timeline

Start

2025-04-06

Primary completion

2028-03-28

Completion

2028-03-28

Drugs

Indications