drugset / Trial / NCT05630209

Blood Brain Barrier (BBB) Disruption Using Exablate Focused Ultrasound With Doxorubicin for Treatment of Pediatric Diffuse Intrinsic Pontine Gliomas (DIPG)

NCT05630209

Phase 1/2 Active not recruiting 10 enrolled InSightec
NaSingle-groupOpen-labelDevice feasibility

Summary

The purpose of this study is to evaluate the safety and efficacy of targeted blood brain barrier disruption with Exablate Model 4000 Type2.0/2.1 in combination with Doxorubicin therapy for the treatment of DIPG in pediatric patients

Timeline

Start
2023-01-04
Primary completion
2026-06
Completion
2026-10

Drugs

EvaluationDrugModalityDoseRoute
Subject Doxorubicin Other / unclassified

Indications