Whole Blood in Trauma Patients With Hemorrhagic Shock

Phase 3 Recruiting 220 enrolled Fundacion Clinica Valle del Lili Hospital Universitario del Valle Evaristo Garcia · collab University of Pittsburgh · collab

RandomizedParallel-groupOpen-labelTreatment

Summary

This study aims to evaluate among trauma patients with hemorrhagic shock the clinical impact of hemostatic resuscitation between whole blood vs. blood components therapy in the following outcomes in a hierarchical analysis: mortality at 28 days and evolution of organ dysfunction.

Timeline

Start: 2023-01-14
Primary completion: 2025-12
Completion: 2026-03

Publications

Garcia AF, Caicedo Y, Gempeler A, Vallecilla L, Macia C, Orlas C, Fernandez MI, Lancheros-Ramirez P, Quintero M, Hernandez E, Vargas S, Cardenas-Perez L, Ariza F, Zarama V, Carvajal S, Billefals E, Sanchez A, Badiel M, Rosso F, Granados M, Albornoz LA, Puyana JC, Ospina-Tascon G, Ordonez CA. Transfusion of modified whole blood versus blood components therapy in patients with severe trauma: Randomized controlled trial protocol (WEBSTER trial). Injury. 2025 May;56(5):112173. doi: 10.1016/j.injury.2025.112173. Epub 2025 Jan 23.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	BLOOD, WHOLE	Other / unclassified	3 unknown	—
Subject	Plasma	Other / unclassified	3 unknown	—
Subject	Platelets	Other / unclassified	3 unknown	—
Subject	Transfusion of blood products	Other / unclassified	3 unknown	—

Indications

No indication recorded.