drugset / Trial / NCT05635851

NO AD: Use of Nitric Oxide (NO) Donors for the Prevention of Autonomic Dysreflexia (AD) During Bowel Care Following SCI

NCT05635851

Phase 2 Not yet recruiting 26 enrolled Simon Fraser University University of British Columbia · collab
RandomizedCrossoverQuadruple-blindSupportive care

Summary

This project aims to evaluate the safety and efficacy of using a short-acting drug to reduce the maximal blood pressure during dangerous blood pressure spikes that happen during bowel care in individuals with spinal cord injury. the investigators will monitor the physiological effects of this drug during at-home bowel care to best understand the drug's effects in typical use.

Timeline

Start
2026-12
Primary completion
2028-02
Completion
2028-02

Drugs

EvaluationDrugModalityDoseRoute
Subject Nitroglycerin Unknown 0.4 mg Other