Dupilumab Step-down Strategy to Maintain Remission in Adult and Adolescents Patients With Atopic Dermatitis

Summary

The goal of this clinical trial is to compare a step-down strategy of spacing dupilumab injections with a standard maintenance treatment in adolescents and adults with controlled Atopic dermatitis (AD) for at least six months. The impact of dosage reduction strategies will be assessed with an innovative primary endpoint: the area under the curve of the weekly ADCT assessment.

Timeline

Start

2023-03-08

Primary completion

2026-09-08

Completion

2026-09-08

Publications

• Foureau A, Faurel-Paul E, Hardouin JB, Papinot L, Schirr-Bonnans S, Tessier P, Jobert A, Poinas A, Staumont-Salle D, Tauber M, Chosidow O, Barbarot S, Aubert H; the FRench Atopic DErmatitis Network from de GREAT Research group. Dupilumab step-down strategy to maintain remission in adult and adolescent patients with atopic dermatitis: study protocol for a non-inferiority randomized trial (MADULO). Trials. 2025 Dec 5;27(1):26. doi: 10.1186/s13063-025-09325-4.

Drugs

Indications