drugset / Trial / NCT05645276

A Study of AK129 in Patients With Advanced Malignant Tumors

NCT05645276

Phase 1 Recruiting 182 enrolled Akeso
NaSingle-groupOpen-labelTreatment

Summary

A Phase Ia/Ib, open label, dose escalation and dose extension trial of Anti-PD-1 and LAG-3 bispecific antibody, AK129, to evaluate the safety, tolerability and antitumor efficacy in patients with advanced malignant tumors

Timeline

Start
2023-03-02
Primary completion
2026-02
Completion
2026-06

Drugs

EvaluationDrugModalityDoseRoute
Subject AK129 Unknown 0.03 mg/kg Intravenous
Subject AK129 Unknown 0.1 mg/kg Intravenous
Subject AK129 Unknown 0.3 mg/kg Intravenous
Subject AK129 Unknown 1 mg/kg Intravenous
Subject AK129 Unknown 3 mg/kg Intravenous
Subject AK129 Unknown 10 mg/kg Intravenous
Subject AK129 Unknown 25 mg/kg Intravenous