drugset / Trial / NCT05645289
Efficacy and Safety of Minodronate in Patients With Low Back Pain
RandomizedParallel-groupOpen-labelTreatment
Summary
This study will provide objective evidence for the efficiency and safety of minodronate in the treatment of postmenopausal osteoporosis with low back pain protocol. Furthermore, it will be helpful to evaluate the quantitative relationship between bone metabolic markers (BTM) and bone mineral density (BMD) in patients with osteoporosis under different ages.
Timeline
- Start
- 2023-01-01
- Primary completion
- 2023-12-31
- Completion
- 2024-04-01
Publications
- Background Yoshioka T, Okimoto N, Okamoto K, Sakai A. A comparative study of the effects of daily minodronate and weekly alendronate on upper gastrointestinal symptoms, bone resorption, and back pain in postmenopausal osteoporosis patients. J Bone Miner Metab. 2013 Mar;31(2):153-60. doi: 10.1007/s00774-012-0393-x. Epub 2012 Oct 19.
- Wang H, Huang J, Tao L, Liu D, Song C. Efficacy and safety of minodronate in the treatment of postmenopausal osteoporosis with low back pain: a single-centre, randomized and open-label controlled trial. Trials. 2024 Aug 13;25(1):534. doi: 10.1186/s13063-024-08364-7.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Alendronic Acid | Small molecule | 10 mg | Oral |
| Subject | Minodronic acid | Small molecule | 1 mg | Oral |