An Open-Label Study Evaluating Brexanolone in Adults With Tinnitus

Summary

The primary objective of this study is to evaluate the safety and tolerability of brexanolone in participants with tinnitus following a single 6-hour continuous intravenous (IV) infusion.

Timeline

Start

2023-05-10

Primary completion

2023-11-21

Completion

2023-11-21

Publications

• Watson LS, O'Donnell P, Bankole K, Toubouti Y, Tyler RS, Johannesen JK. An open-label, proof-of-mechanism trial evaluating a neuroactive steroid GABA modulator in tinnitus. Front Neurol. 2025 Nov 18;16:1662226. doi: 10.3389/fneur.2025.1662226. eCollection 2025.

Drugs

Indications