drugset / Trial / NCT05646836

A Study to Evaluate the Safety, Pharmacokinetics, and Activity of XmAb24306 in Combination With Cevostamab in Participants With Relapsed/Refractory Multiple Myeloma

NCT05646836

Phase 1 Active not recruiting 90 enrolled Genentech, Inc.
Non-randomizedSequentialOpen-labelTreatment

Summary

The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics, and activity of XmAb24306 in combination with cevostamab in participants with relapsed/refractory multiple myeloma (R/R MM) who have received a minimum of three prior treatments, including at least one immunomodulatory drug (IMiD), one proteasome inhibitor (PI), and one anti-CD38 monoclonal antibody.

Timeline

Start
2023-03-21
Primary completion
2026-11-18
Completion
2026-11-18

Drugs

EvaluationDrugModalityDoseRoute
Subject Cevostamab Monoclonal antibody Intravenous
Subject XmAb24306 Unknown Intravenous
Background Tocilizumab Monoclonal antibody

Indications