drugset / Trial / NCT05657444
Intra-arterial Tenecteplase During First Thrombectomy Attempt for Acute Stroke (BRETIS-TNK II)
Phase 3
Completed
380 enrolled
General Hospital of Shenyang Military Region
Cerebrovascular Disease Collaboration & Innovation Alliance of Liaoning · collab
RandomizedParallel-groupSingle-blindTreatment
Summary
A recent pilot study suggests intra-arterial tenecteplase (TNK) during the first pass of endovascular treatment (EVT) seems safe, may increase first-pass reperfusion and good outcome in acute ischemic stroke (AIS) patients with large vessel occlusion (LVO). The study aimed to determine the efficacy and safety of intra-arterial TNK administration during EVT in AIS-LVO patients.
Timeline
- Start
- 2023-03-21
- Primary completion
- 2025-03-20
- Completion
- 2025-03-20
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Tenecteplase | Protein / enzyme biologic | — | Other |