drugset / Trial / NCT05668936

A Thorough QTC Study to Assess the Effect of Cotadutide on Cardiac Repolarization in Healthy Participants

NCT05668936 ↗

Phase 1 Terminated 31 enrolled AstraZeneca
RandomizedParallel-groupDouble-blindTreatment

Summary

This study will investigate the effect of multiple doses of cotadutide on the cardiac activity (QTc interval) of healthy participants.

Timeline

Start
2023-01-03
Primary completion
2023-03-10
Completion
2023-03-10

Outcome

Outcome not reported

Stopped (Business): “Discontinuing the development of cotadutide, a daily injectable GLP-1/glucagon co-agonist, is based on strategic pipeline considerations. The premature closure is not due to any newly observed safety signals or a change in the risk/benefit profile.”

Drugs

EvaluationDrugModalityDoseRoute
Subject Cotadutide Peptide — Subcutaneous
Subject Moxifloxacin Small molecule — Oral