drugset / Trial / NCT05693077
Clostridioides Difficile Colonisation
RandomizedParallel-groupQuadruple-blindPrevention
Summary
This study will investigate experimental colonisation with non-toxigenic C.difficile (NTCD) in healthy volunteers. Main outcomes will be safety, tolerability, dose needed to obtain colonisation with NTCD to ultimately determine host microbiota factors associated with susceptibility to colonisation.
Timeline
- Start
- 2023-09-22
- Primary completion
- 2024-06
- Completion
- 2025-06
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | 10E4 NTCD spores | Unknown | — | Oral |
| Subject | 10E7 NTCD spores | Unknown | — | Oral |
| Background | Vancomycin | Other / unclassified | 250 mg | Oral |