Acute Dose-dependent Effects of DMT-bolus Applications in Healthy Subjects (DMT BDR-Study)

Phase 1 Completed 36 enrolled University Hospital, Basel, Switzerland

RandomizedCrossoverTriple-blindBasic science

Summary

N,N-dimethyltryptamine (DMT) is a psychoactive substance with similar effects such as LSD or psilocybin. However, DMT is less well characterized than the latter substances. The present study is a modern randomized cross-over trial, investigating different intravenous DMT boluses over a broad dose range. Thus, different doses will be tested and related to subjective and autonomic effects.

Timeline

Start: 2024-06-12
Primary completion: 2025-02-02
Completion: 2025-03-04

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	N,N-Dimethyltryptamine	Unknown	5 mg	Intravenous
Subject	N,N-Dimethyltryptamine	Unknown	10 mg	Intravenous
Subject	N,N-Dimethyltryptamine	Unknown	15 mg	Intravenous
Subject	N,N-Dimethyltryptamine	Unknown	20 mg	Intravenous
Subject	N,N-Dimethyltryptamine	Unknown	25 mg	Intravenous

Indications

No indication recorded.