drugset

drugset / Trial / NCT05701956

Intravenous Tenecteplase Plus EVT Versus EVT Alone on 4.5 to 24 Hours After Basilar Artery Occlusion

NCT05701956 ↗

Phase 3 Completed 330 enrolled The First Affiliated Hospital of University of Science and Technology of China

RandomizedParallel-groupSingle-blindTreatment

Summary

To assess the effect of intravenous tenecteplase plus endovascular thrombectomy (EVT) compared to EVT alone on 4.5 to 24 hours after stroke due to basilar artery occlusion.

Timeline

Start: 2023-03-16
Primary completion: 2025-02-04
Completion: 2025-05-04

Publications

Li R, Nguyen T, Tao C, Sun J, Xu P, Luo C, Wang L, Liu T, Song J, Jing X, Wang A, Qureshi AI, Abdalkader M, Saver JL, Nogueira RG, Hu W. Intravenous tenecteplase before endovascular thrombectomy in patients with acute basilar artery occlusion within 4.5-24 hours: study protocol and rationale. Stroke Vasc Neurol. 2026 Apr 7:svn-2025-004275. doi: 10.1136/svn-2025-004275. Online ahead of print.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Tenecteplase	Protein / enzyme biologic	0.25 mg/kg	Intravenous

Indications