Artificial Tears, Tear Lipids and Tear Film Dynamics

Summary

Dry eye disease (DED) is pervasive with some reports estimating over 16 million adults diagnosed in the United States. Currently, artificial tears remain an integral part of managing dry eyes and are mainly used for symptomatic relief. Recent studies have shown there may be therapeutic benefits with regular use of lipid-based artificial tears to improve the structure of the tear film, which may improve tear film stability and provide relief of symptoms. In this study the investigators propose to compare effects on the tear lipid film and its dynamics between 3 lipid based artificial tears and a widely available non-lipid based artificial tear.

Timeline

Start

2023-01-30

Primary completion

2023-09-30

Completion

2024-01-30

Publications

• Ding JE, Pradhan A, Ma DK, FazioLiu AJ, Chang SM, Graham AD, Leung DJ, Wu RS, Zhou Y, Svitova T, Yeh TN, Lin MC. Randomized comparison of lipid-containing and non-lipid-containing artificial tears on tear film dynamics over a 3-month period. Optom Vis Sci. 2026 Jul;103(7):e70084. doi: 10.1002/ovs2.70084.

Drugs

Indications