drugset / Trial / NCT05709821

IMM60 and Pembrolizumab in Melanoma and NSCLC

NCT05709821 ↗

Phase 1/2 Terminated 1 enrolled iOx Therapeutics Merck Sharp & Dohme LLC · collab
RandomizedParallel-groupOpen-labelTreatment

Summary

The goal of this clinical trial is to learn about IMM60 with or without pembrolizumab in participants with advanced melanoma or non-small cell lung cancer. There are two phases: * Phase 1: This phase is designed to learn about the safety of IMM60 with or without pembrolizumab and to find a safe dose to test in Phase 2. * Phase 2: This phase is designed to learn whether IMM60 + pembrolizumab improves progression-free survival at 12 months compared to pembrolizumab alone in participants with non-small cell lung cancer.

Timeline

Start
2023-11-15
Primary completion
2024-04-22
Completion
2024-04-22

Outcome

Outcome not reported

Stopped: “Prioritization of other pipeline assets. No safety or efficacy issues were observed.”

Drugs

EvaluationDrugModalityDoseRoute
Subject IMM60 Unknown 1 mg/m2 Intravenous
Subject IMM60 Unknown 3 mg/m2 Intravenous
Subject IMM60 Unknown 9 mg/m2 Intravenous
Subject IMM60 Unknown 36 mg/m2 Intravenous
Subject Pembrolizumab Monoclonal antibody 200 mg Intravenous