drugset / Trial / NCT05709821
IMM60 and Pembrolizumab in Melanoma and NSCLC
RandomizedParallel-groupOpen-labelTreatment
Summary
The goal of this clinical trial is to learn about IMM60 with or without pembrolizumab in participants with advanced melanoma or non-small cell lung cancer. There are two phases: * Phase 1: This phase is designed to learn about the safety of IMM60 with or without pembrolizumab and to find a safe dose to test in Phase 2. * Phase 2: This phase is designed to learn whether IMM60 + pembrolizumab improves progression-free survival at 12 months compared to pembrolizumab alone in participants with non-small cell lung cancer.
Timeline
- Start
- 2023-11-15
- Primary completion
- 2024-04-22
- Completion
- 2024-04-22
Outcome
Outcome not reported
Stopped: “Prioritization of other pipeline assets. No safety or efficacy issues were observed.”
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | IMM60 | Unknown | 1 mg/m2 | Intravenous |
| Subject | IMM60 | Unknown | 3 mg/m2 | Intravenous |
| Subject | IMM60 | Unknown | 9 mg/m2 | Intravenous |
| Subject | IMM60 | Unknown | 36 mg/m2 | Intravenous |
| Subject | Pembrolizumab | Monoclonal antibody | 200 mg | Intravenous |