Effect of Subanesthetic Dose of Esketamine on Sleep Quality and Recovery of Gastrointestinal Function in Patients Undergoing General Anesthesia Laparoscopic Uterine Surgery in the Early Postoperative Period

Summary

Patients undergoing gynecological surgery are at high risk of developing postoperative sleep disorders. Intraoperative opioid use is detrimental to the patient's postoperative recovery of gastrointestinal function. Esketamine has sedative, hypnotic, analgesic, inflammatory response suppression, and antidepressant effects. Its hypnotic mechanism may be related to its rapid blockade of NMDA receptors and hyperpolarization-activated cyclic nucleotide-gated cation channels. Also can reduce the application of perioperative opioids, which in turn promotes the recovery of gastrointestinal function in patients after surgery.

Timeline

Start

2023-03-25

Primary completion

2023-11-30

Completion

2023-12-31

Publications

• Yuan B, Tian S, Pu X, Yin J, Wang M, Feng S, Lv X, Sun Y, Yao H, Li M, Li S, Zhang Z. Esketamine improves postoperative sleep quality in women undergoing gynecological laparoscopy: A prospective, randomized, double-blind, and controlled trial. Sleep Med. 2025 Dec;136:106852. doi: 10.1016/j.sleep.2025.106852. Epub 2025 Oct 14.

Drugs

Indications

No indication recorded.