Clinical Outcomes of Cyclosporine Eye Drops in Management of Herpetic Keratitis

Summary

Objective: To compare the additive effect of topical cyclosporine A 0.05% eye drops to prednisolone eye drops, with topical prednisolone acetate 1% eye drops alone in treatment of herpetic stromal keratitis. Methods: Patients diagnosed with herpetic stromal keratitis are randomly divided into 2 groups; Group A: receive cyclosporine eye drops together with prednisolone eye drops. Group B: receive topical prednisolone with placebo eye drops (tear replacement). The 2 groups receive systemic acyclovir therapeutic dose 400 mg five times daily, which then tapered to twice daily prophylactic dose after one month of treatment. Follow up for patients is scheduled as a weekly visit for a duration of 2 months.

Timeline

Start

2022-01-01

Primary completion

2024-03-01

Completion

2024-03-01

Publications

• Lotfy NM, Alshatti H, Khachaba RY, Hagras SM. Evaluation of safety and efficacy of cyclosporine-A eye drops in herpetic stromal keratitis: a prospective randomized clinical trial. J Ophthalmic Inflamm Infect. 2026 Mar 5;16(1):14. doi: 10.1186/s12348-026-00573-2.

Drugs

Indications