drugset / Trial / NCT05726019

Colchicine in Patients Undergoing Coronary Artery Bypass Grafting After Acute Coronary Syndrome

NCT05726019

Phase 2 Completed 100 enrolled University of Sao Paulo General Hospital
RandomizedParallel-groupSingle-blindPrevention

Summary

The present study seeks to evaluate the effectiveness of the use of perioperative colchicine with regard to operative complications, in patients with acute coronary syndrome and indication for cardiac post-surgical revascularization. Patients will be selected and randomized while still in the emergency room and medication (colchicine 0.5mg every 12 hours or placebo) will be started within 24 hours of randomization, being maintained for 30 days after surgery.

Timeline

Start
2022-02-05
Primary completion
2025-12-21
Completion
2025-12-21

Drugs

EvaluationDrugModalityDoseRoute
Comparator Colchicine Small molecule 0.5 mg Oral