Improving Physical Function in Older Adults Using an Anti-inflammation Drug: The RIGHT Study

Summary

The goal of this clinical trial is to learn about the effects of inflammation-lowering therapy on mobility and disability in older adults. The main questions it aims to answer are: * Will therapy improve walking speed/pace? * Will therapy improve levels of blood inflammation markers and other indicators of physical, cognitive and immune function? Participants will be asked to receive injections of drug or placebo every 4 weeks for 24 weeks. They will also be asked to undergo testing that assesses physical function, thinking ability and brain health, breathing capacity, and blood vessel stiffness, and will have blood samples collected to measure immune function and to create a bank of samples for future testing. Comparisons will be made between those who receive drug and those who receive placebo.

Timeline

Start

2023-08-01

Primary completion

2026-01-05

Completion

2026-05-26

Publications

• Sattui SE, Bertolet M, Forman DE, Danielson ME, Yao S, Lopez OL, Glynn NW, Nadkarni NK, Sekikawa A, Bruno TC, Finkel T, Newman AB. The "Reducing Inflammation for Greater Health Trial (RIGHT)" Study-Concept, Rationale, and Design. J Am Geriatr Soc. 2026 Mar;74(3):636-647. doi: 10.1111/jgs.70272. Epub 2026 Jan 10.

Drugs

Indications

No indication recorded.