drugset / Trial / NCT05728645
Colloid Infusion for Optimal Outcomes In Non-cardiac Surgery (COIN Trial)
Completed
2022 enrolled
Xijing Hospital
First Affiliated Hospital of Chongqing Medical University · collabNingbo No.2 Hospital · collabShenzhen University General Hospital · collabThe Affiliated Hospital Of Guizhou Medical University · collabThe Second Affiliated Hospital of Dalian Medical University · collabYan'an University Affiliated Hospital · collab
RandomizedParallel-groupQuadruple-blindPrevention
Summary
Hypotension is associated with postoperative complications. Preoperative fluid infusion can effectively prevent post-induction hypotension of general anesthesia. Previous studies only focused on the hemodynamics after preoperative fluid infusion. Pre-operative fluid infusion can reduce the incidence of post-operative complications by preventing post-induction hypotension. The patients who is 18 years or older and undergo elective non-cardiac surgery with general anesthsia will be enrolled. The intervention is intravenous infusion of colloids or crytalloids before induction of general anesthesia. The primary outcome is the incidence of post-operative complications within 30 days.
Timeline
- Start
- 2023-07-12
- Primary completion
- 2025-03-28
- Completion
- 2025-08-31
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Multiple Electrolytes injection | Unknown | 5 unknown | Intravenous |
| Subject | Volulyte | Other / unclassified | 5 unknown | Intravenous |
Indications
No indication recorded.