drugset / Trial / NCT05731518
SC0245 and Irinotecan in Treating Patients With Relapsed Extensive-Stage Small Cell Lung Cancer (ES-SCLC)
NaSingle-groupOpen-labelTreatment
Summary
This study is a single arm, multi-center, open label phase Ib/II study of SC0245 and Irinotecan combination therapy in subjects with extensive-stage small cell lung cancer (ES-SCLC) as a second therapy. This study will have three parts, phase 1 dose escalation (Part 1), phase 1 dose expansion (Part 2), and phase 2 combination therapy (Part 3).
Timeline
- Start
- 2023-02-23
- Primary completion
- 2025-09-30
- Completion
- 2026-02-28
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | SC0245 | Unknown | — | — |
| Background | Irinotecan | Small molecule | 80 mg/m2 | Intravenous |