drugset / Trial / NCT05731947

Evaluation of Revumenib in Participants With Colorectal Cancer and Other Solid Tumors

NCT05731947 ↗

Phase 1/2 Terminated 41 enrolled Syndax Pharmaceuticals
Non-randomizedSequentialOpen-labelTreatment

Summary

This study will evaluate the safety, tolerability, pharmacokinetics (PK), and anti-tumor activity of revumenib in participants with colorectal cancer (CRC) or other solid tumors who have failed at least 1 prior line of therapy.

Timeline

Start
2023-04-04
Primary completion
2025-06-30
Completion
2025-06-30

Outcome

Outcome not reported

Stopped: “Study was terminated by sponsor after Phase 1b as pre-defined signals of efficacy were not met in the Phase 1b dose expansion cohort.”

Drugs

EvaluationDrugModalityDoseRoute
Subject Lonsurf Unknown — —
Subject Regorafenib Small molecule — —
Subject Revumenib Small molecule — Oral

Indications