drugset / Trial / NCT05731947
Evaluation of Revumenib in Participants With Colorectal Cancer and Other Solid Tumors
Non-randomizedSequentialOpen-labelTreatment
Summary
This study will evaluate the safety, tolerability, pharmacokinetics (PK), and anti-tumor activity of revumenib in participants with colorectal cancer (CRC) or other solid tumors who have failed at least 1 prior line of therapy.
Timeline
- Start
- 2023-04-04
- Primary completion
- 2025-06-30
- Completion
- 2025-06-30
Outcome
Outcome not reported
Stopped: “Study was terminated by sponsor after Phase 1b as pre-defined signals of efficacy were not met in the Phase 1b dose expansion cohort.”
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Lonsurf | Unknown | — | — |
| Subject | Regorafenib | Small molecule | — | — |
| Subject | Revumenib | Small molecule | — | Oral |