Effect of L-ornithine-L-aspertate (LOLA) on the Gut Microbiome

Phase 4 Completed 52 enrolled Medical University of Graz CBmed Ges.m.b.H. · collab

NaSingle-groupOpen-labelTreatment

Summary

Study to test the effect of the drug "L-ornithine.L-aspertate" (LOLA) on microorganisms in the digestive tract in patients with liver cirrhosis (damage of the liver due to liver disease)

Timeline

Start: 2023-02-06
Primary completion: 2024-07-23
Completion: 2025-12-31

Outcome

Missed primary endpoint

paper Although our primary endpoint was not reached PMID 41406626 ↗

Publications

Habich D, Horvath A, Feldbacher N, Rebol L, Nepel M, Madl T, Habisch HJ, Baumann-Durchschein F, Furst S, Plank J, Rainer F, Spindelbock W, Stauber RE, Tatscher E, Wagner M, Zollner G, Stadlbauer V. An observational study on the effect of l-ornithine-l-aspartate (LOLA) on the gut microbiome in liver cirrhosis. A single center phase 4 study. Clin Nutr. 2026 Jan;56:106522. doi: 10.1016/j.clnu.2025.11.007. Epub 2025 Nov 29.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	L-ornithine L-aspartate	Other / unclassified	18 g	Oral