Safety and Efficacy of Pluripotent Stem Cell-derived Mesenchymal Stem Cell Exosome (PSC-MSC-Exo) Eye Drops Treatment for Dry Eye Diseases Post Refractive Surgery and Associated With Blepharospasm

Phase 1/2 Unknown 12 enrolled Second Affiliated Hospital, School of Medicine, Zhejiang University Hangzhou yuansheng biotechnology Co., Ltd · collab Zhejiang University · collab

NaSingle-groupOpen-labelTreatment

Summary

The purpose of this study is to evaluate the preliminary safety and effectiveness of Pluripotent Stem Cell-derived Mesenchymal Stem Cell Exosome (PSC-MSC-Exo) Eye Drops in the treatment of dry eye diseases post refractive surgery and associated with blepharospasm

Timeline

Start: 2023-03
Primary completion: 2025-02
Completion: 2025-02

Publications

Randall Harrell C, Djonov V, Volarevic A, Arsenijevic A, Volarevic V. Mesenchymal Stem Cell-Sourced Exosomes as Potentially Novel Remedies for Severe Dry Eye Disease. J Ophthalmol. 2025 Jan 10;2025:5552374. doi: 10.1155/joph/5552374. eCollection 2025.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Pluripotent Stem Cell-derived Mesenchymal Stem Cell Exosome	Other / unclassified	0.125 ml	Other

Safety and Efficacy of Pluripotent Stem Cell-derived Mesenchymal Stem Cell Exosome (PSC-MSC-Exo) Eye Drops Treatment for Dry Eye Diseases Post Refractive Surgery and Associated With Blepharospasm

Summary

Timeline

Publications

Drugs

Indications