drugset / Trial / NCT05745987

Smallpox Vaccine for Mpox Post-Exposure Prophylaxis: A Cluster RCT

NCT05745987

Phase 4 Recruiting 3000 enrolled McMaster University
RandomizedParallel-groupTriple-blindPrevention

Summary

A cluster randomized controlled trial to determine if smallpox vaccine reduces secondary cases and symptom severity in persons exposed to mpox.

Timeline

Start
2024-09-17
Primary completion
2026-06-01
Completion
2026-12-01

Drugs

EvaluationDrugModalityDoseRoute
Subject IMVAMUNE Vaccine 0.5 ml
Comparator Typhim Vi Vaccine 0.5 ml

Indications