drugset / Trial / NCT05746039

Feasibility of Semaglutide in Advanced Lung Disease

NCT05746039

Phase 1/2 Recruiting 8 enrolled University of Pennsylvania
NaSingle-groupOpen-labelTreatment

Summary

The goal of this clinical trial is to learn whether semaglutide, an FDA-approved treatment for diabetes and obesity, is feasible and tolerable in patients with advanced lung disease. The main question\[s\] it aims to answer are: 1. Are patients with advanced lung disease able to tolerate semaglutide therapy? 2. Are we able to titrate semaglutide therapy to a target weight? Participants will be asked to perform pulmonary function, physical function and body composition testing, as well as a blood draw before and after 12-weeks of semaglutide therapy. While on therapy, subjects will be surveyed regarding any adverse events or side effects.

Timeline

Start
2024-01-29
Primary completion
2027-12-28
Completion
2027-12-28

Drugs

EvaluationDrugModalityDoseRoute
Subject Semaglutide Peptide 1 mg Subcutaneous