Prevention of Post-Operative Nausea and Vomiting With Propofol Infusion

Phase 2 Completed 68 enrolled Milton S. Hershey Medical Center

RandomizedParallel-groupSingle-blindTreatment

Summary

The purpose of this study is to clarify whether or not a low-dose propofol infusion can effectively prevent postoperative nausea and vomiting (PONV) in patients who have a documented history of PONV and/or motion sickness.

Timeline

Start: 2024-02-01
Primary completion: 2025-03-12
Completion: 2025-03-12

Outcome

Missed primary endpoint

paper At 24 h, PONV was reported by 59% in the hybrid group and 42% in the TIVA group (p = 0.17). PMID 41593496 ↗

paper CONCLUSION: Low-dose propofol infusion combined with sevoflurane resulted in PONV rates that were not statistically different from propofol-based TIVA. PMID 41593496 ↗

Publications

Keck WL, Deng E, Liu WM, Kanekar R, Lomivorotov V, Sharma S. Effect of low-dose propofol infusion with sevoflurane versus propofol-only total intravenous anesthesia on postoperative nausea and vomiting in high-risk patients: a single-blind randomized controlled clinical trial. BMC Anesthesiol. 2026 Jan 28;26(1):136. doi: 10.1186/s12871-026-03649-7.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Propofol	Small molecule	25 ug/kg	Intravenous

Indications

No indication recorded.