drugset / Trial / NCT05766345
BCG-induced Epigenetic Modifications in the NEXT Generation
RandomizedParallel-groupSingle-blindBasic science
Summary
Non-specific protective effects resulting from the BCG vaccine appear to be paternally inheritable. Since the BCG vaccine is known to induce trained immunity, epigenetics might explain the fathers' contribution to the immune profile of their offspring. Epigenetic inheritance in mice has recently been demonstrated, but is not established in humans yet. By studying the DNA methylation profile of sperm cells after BCG vaccination, we aim to gain insight into the possibility of epigenetic inheritance in human males.
Timeline
- Start
- 2023-10-02
- Primary completion
- 2024-08
- Completion
- 2024-10
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | BCG vaccine SSI | Vaccine | 0.0075 mg | Other |
| Subject | BCG vaccine SSI | Vaccine | 0.1 ml | Other |
Indications
No indication recorded.