18F-LY3950321-01 Biodistribution and Safety Study

Phase 0 Completed 6 enrolled Avid Radiopharmaceuticals

NaSingle-groupOpen-labelDiagnostic

Summary

18F-LY3950321 (also known as 18F-MNI-1256) is a radiolabeled positron emission tomography (PET) tracer targeting granzyme B. The overall goal of this protocol is to evaluate the safety, tolerability, and radiation dosimetry of 18F-LY3950321.

Timeline

Start: 2023-02-28
Primary completion: 2023-04-04
Completion: 2023-04-04

Publications

Background Stabin MG, Sparks RB, Crowe E. OLINDA/EXM: the second-generation personal computer software for internal dose assessment in nuclear medicine. J Nucl Med. 2005 Jun;46(6):1023-7.
Background International Commission on Radiological Protection. Human alimentary tract model for radiological protection. ICRP Publication 100. A report of The International Commission on Radiological Protection. Ann ICRP. 2006;36(1-2):25-327, iii. doi: 10.1016/j.icrp.2006.03.004.
Background Harrison J, Lopez PO. Use of effective dose in medicine. Ann ICRP. 2015 Jun;44(1 Suppl):221-8. doi: 10.1177/0146645315576096. Epub 2015 Mar 25.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	18F-LY3950321	Diagnostic / imaging agent	111 mbq	—

Indications

No indication recorded.