drugset / Trial / NCT05786066
The Impact of AMPA Receptor Blockade on Ketamine's Anti-Suicidal Effects
Phase 2
Recruiting
30 enrolled
Yale University
American Foundation for Suicide Prevention · collabNational Center for PTSD · collabVA Connecticut Healthcare System · collab
RandomizedCrossoverDouble-blindBasic science
Summary
The purpose of this study is to test the hypothesis that the anti-depressant and anti-suicidal effects of the N-methyl-D-aspartate receptor (NMDAR) antagonist Ketamine is critically dependent on stimulation of Alpha-Amino-3-Hydroxy-5-Methyl-4-Isoxazole Propionic Acid receptors (AMPAR).
Timeline
- Start
- 2023-04-03
- Primary completion
- 2033-03
- Completion
- 2033-03
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Ketamine | Small molecule | 0.5 mg/kg | — |
| Subject | Perampanel | Small molecule | 6 mg | Oral |