Congrong Runtong Oral Liquid in the Treatment of Functional Constipation (Yang-deficiency Type)

Summary

Using a placebo as a control, this study aims to preliminarily evaluate the clinical efficacy of Congrong Runtong oral liquid for the treatment of functional constipation (Yang-deficiency type), explore the optimal dosage of Congrong Runtong oral liquid for functional constipation (Yang-deficiency type) to provide a basis for dosage selection in Phase III clinical trials, and observe the safety of clinical use of Congrong Runtong oral liquid.

Timeline

Start

2023-03-29

Primary completion

2024-04-01

Completion

2024-04-01

Outcome

Met primary endpoint

paper p < 0.0001 for 6g/d vs placebo PMID 41759423 ↗

paper p = 0.044 for 3g/d vs placebo PMID 41759423 ↗

Publications

• Zhao L, Sun X, Zhu L, Chen B, Qin D, Fang S, Gao J, Liu C, Wu H, Liu F, Shen D, Zhao L, Zhang S. Congrong Runtong oral liquid for functional constipation: A multicenter, placebo-controlled phase II trial. Phytomedicine. 2026 Apr;153:157991. doi: 10.1016/j.phymed.2026.157991. Epub 2026 Feb 21.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Congrong Runtong oral liquid	Unknown	1 g	Oral
Subject	Congrong Runtong oral liquid	Unknown	2 g	Oral

Indications