The Prevention of Systemic Ectopic Mineralization in Pseudoxanthoma Elasticum

Summary

The goal of this randomized clinical trial is to assess the effect of etidronate on ectopic calcification in relatively young patients with Pseudoxanthoma elasticum. The main question it aims to answer are: What is the difference in the arterial calcification scores in the legs and the carotid syphon measured on low-dose CT scan after 24 months of treatment compared to baseline between etidronate and placebo. Participants will be asked to do take etidronate or placebo for 24 months.

Timeline

Start

2023-04-26

Primary completion

2027-03-29

Completion

2027-04-29

Publications

• Harmsen IM, Haverkamp M, van den Beukel TC, Kok M, de Jong PA, van Valen E, van Leeuwen R, Norel JO, Spiering W. The TEMP-PREVENT trial: a study protocol for a randomized, double-blind, placebo-controlled clinical trial of etidronate for treatment in young adult patients with pseudoxanthoma elasticum. Trials. 2025 Oct 23;26(1):431. doi: 10.1186/s13063-025-09064-6.

Drugs

Indications