drugset / Trial / NCT05839561
Monotherapy With Letrozole in Tubal Pregnancy
Non-randomizedParallel-groupOpen-labelTreatment
Summary
It is hypothesized that the inhibition of estradiol production by letrozole may interfere with physiological effects of progesterone necessary to maintain the pregnancy. Treatment of tubal pregnancy with letrozole would allow to avoid the adverse effects of methotrexate (MTX) in women refusing surgery. The aim was to compare the effectiveness of letrozole with MTX in the management of tubal pregnancy.
Timeline
- Start
- 2020-12-01
- Primary completion
- 2022-12-30
- Completion
- 2023-06-30
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Letrozole | Other / unclassified | 5 mg | Oral |
| Comparator | Methotrexate | Small molecule | 100 mg | Intravenous |