Polygenic Risk-based Detection of Subclinical Coronary Atherosclerosis and Intervention With Statin and Colchicine

Summary

The goal of this double-blind randomized controlled trial is to determine how treatment with high intensity statin, low-dose colchicine, and their combination modulates progression and composition of coronary atherosclerosis in individuals with high polygenic risk for coronary artery disease.

Timeline

Start

2023-12-07

Primary completion

2027-06-01

Completion

2027-06-01

Publications

• Abou-Karam R, Kim MS, Jemma Cho SM, Bitar F, Gady S, Cheng F, Thompson AG, Karlson EW, Natarajan P, Ellinor PT, Foldyna B, Ghebremichael MS, Atlas SJ, Ridker PM, Lu MT, Fahed AC. Polygenic Risk Based Detection and Treatment of Subclinical Coronary Atherosclerosis in the PROACT Clinical Trials. J Am Coll Cardiol. 2026 Feb 6:S0735-1097(25)10563-9. doi: 10.1016/j.jacc.2025.12.032. Online ahead of print.

Drugs

Indications